Chelsea suffered a 2-0 loss to Brentford at Stamford Bridge on Wednesday night, Sportivationng.com reports.
The hosts struggled to create chances and the little they created they spurned as Lampard opted to start with a forward line of Ngolo Kante, Conor Gallagher and Raheem Sterling.
Azpilicueta scored an own goal to give Brentford the lead just before halftime.
Lampard brought on Pierre Emerick Aubameyang and Mykhailo Mudryk for Cesar Azpilicueta and Conor Gallagher in a bid to find a headway.
Bryan Mbuemo added the second goal in the 78th minute to condemn Chelsea to their fifth loss under Frank Lampard in all competitions.
Liverpool continued their resurgence with a 2-1 win over West Ham United thanks to goals from Cody Gakpo and Joel Matip.
Lucas Pacqueta opened the scoring for West Ham in the 12th minute.
Cody Gakpo restored parity for Liverpool before Joel Matip scored the winner in the 67th minute.
Nottingham Forest earned a 3-1 win over Brighton to boost their relegation survival hopes.